H. Pylori Gastric Infection Treatment

What is the H. pylori gastric infection treatment?

Helicobacter pylori (H. pylori) is a type of bacteria that can be present in the stomach lining. H. pylori may exist in the digestive system without causing issues, but in some cases, it can result in an infection of the stomach lining. When infection occurs, it can cause inflammation, ulcers, and long-term damage if left untreated.

Treatment for H. pylori aims to eliminate the bacteria completely. This helps to relieve discomfort, reduce the risk of ulcers, and prevent serious complications like stomach cancer. The treatment also supports the healing of the stomach lining and helps restore healthy digestion.

The most common treatment involves a combination of medications known as “triple therapy.” This includes two antibiotics and a medication to reduce stomach acid. Sometimes, a “quadruple therapy” is used, which adds a third antibiotic or a substance called bismuth to improve results.

The treatment for H. pylori infection usually lasts from 7 to 14 days. After completing the course, your doctor may recommend a follow-up test to confirm that your system has cleared the bacteria.

Benefits of H. pylori gastric infection treatment

Successful treatment of H. pylori brings several essential health benefits. It helps relieve common digestive symptoms such as upper abdominal pain, bloating, nausea, and indigestion. Many patients notice significant improvements after H. pylori treatment. Appetite often returns to normal, making meals more comfortable without pain or bloating. Digestive symptoms like heartburn, nausea, and indigestion also tend to reduce.

More importantly, the treatment prevents the development of more serious conditions. If left untreated, H. pylori can cause peptic ulcers and chronic gastritis. Over time, this damage may increase the risk of stomach cancer. Clearing the infection also improves the quality of life. You are less likely to experience recurring discomfort or need long-term medication for stomach acid.

Am I suitable for the treatment of H. pylori gastric infection?

If you have tested positive for H. pylori, you may be suitable for treatment. Many people are tested after reporting persistent digestive symptoms such as pain, heartburn, bloating, or nausea. Even without symptoms, treatment may still be recommended if the bacteria are found.

People who have had stomach ulcers or gastritis in the past are often advised to undergo treatment, as H. pylori is a common cause of these conditions. If you have a family history of stomach cancer or ulcers, treatment may also be recommended as a preventive step.

Before starting treatment, your doctor will assess your test results, symptoms, medical history, and other health conditions. They will also check if you are allergic to medications and explain what to expect from the treatment process.

Preparing for H. pylori treatment

Typically, no special preparation is needed before starting treatment for H. pylori. However, it is important to discuss this with your doctor before beginning the course of antibiotics.

It is important to let your doctor know if you are allergic to any medications. You should also inform your doctor if you are pregnant, breastfeeding, or taking other prescription drugs. You should also let your doctor know if you’re taking supplements or over-the-counter medicines.

Once treatment begins, it is essential to take all the prescribed medications exactly as instructed. Do not skip doses; try to take the medicine at the same time each day. It is not advised to stop taking the drug, even after you feel better. Skipping the instructed doses may allow the bacteria to survive and become antibiotic-resistant.

What to expect during treatment: Will it be uncomfortable?

Person taking yellow pills with a glass of water, representing H. pylori treatment and potential discomfort during the process.

Treatment for H. pylori usually involves taking two types of antibiotics and an acid-suppressing medication. Depending on the prescribed course, these are taken once or twice daily for about one to two weeks.

Unless your doctor advises otherwise, it is important to take your medication with food and water. Some people may experience mild side effects while on the course of treatment. These may include nausea, changes in taste, bloating, or diarrhoea. Although these side effects can be unpleasant, they are generally temporary and manageable.

To reduce discomfort, eat smaller meals and avoid spicy or acidic foods during treatment. Stay hydrated and continue with light physical activity if you feel up to it.

If side effects become severe or interfere with your daily routine, contact your doctor for advice. They may be able to adjust your medication or suggest ways to ease the symptoms. Most people can complete the course without major issues and feel better within days of finishing treatment.

After the treatment: What should I expect?

Once you finish your H. pylori treatment, your doctor may schedule a follow-up test to check whether the infection has been fully cleared. Most people notice relief from symptoms within a few days to a couple of weeks. If discomfort continues beyond treatment, your doctor may investigate the cause further.

There are usually no strict dietary rules after treatment, but it is helpful to eat a balanced diet that supports digestive health. Avoiding smoking and limiting alcohol intake may also help your stomach heal more quickly. Your doctor may recommend probiotics or other supportive measures to restore your gut balance, especially if you had significant side effects during treatment.

What is the success rate of H. pylori treatment?

H. pylori treatment is highly effective. First-line treatment clears the infection in around 80 to 90 per cent of cases. Success depends on the type of medication used, how well the course is followed, and whether the bacteria are resistant to certain antibiotics.

If the first treatment does not work, your doctor may prescribe a second-line therapy. This often involves different antibiotics or a more extended treatment course. Most people respond well to these adjustments. With careful monitoring and follow-up testing, complete eradication is achievable for most patients.

Are there any side effects? What is the typical recovery time?

Most side effects during H. Pylori treatment is mild. They may include nausea, bloating, diarrhoea, or a metallic taste in the mouth. These usually resolve shortly after the treatment ends.

Recovery is typically quick. Many patients feel better within one to two weeks of finishing their medication. The chances of serious side effects or complications are relatively low and rare. It is important to complete the entire course and let your doctor know if any symptoms worsen or linger longer than expected.

When will I know the results?

After treatment, your doctor will usually arrange a follow-up test to check if the infection is gone. This follow-up test typically involves a urea breath test or stool antigen test and is done about four to six weeks after finishing the course.

Results are usually available within a few days, depending on the test. Your doctor will explain the outcome and let you know if further action is needed. If the bacteria are still present, a second round of treatment may be advised to clear the infection entirely.

Should I repeat H. pylori treatment in the future?

Gloved hand holding a blood sample labeled Helicobacter Pylori, representing testing and consideration for repeating H. pylori treatment

If the infection persists or comes back after your first course of treatment, you may need to repeat treatment. Reinfection of H. pylori is rare but possible, mainly if someone close to you still carries the bacteria and transmission occurs through shared food or utensils.

A follow-up test is important to confirm the infection has been cleared. If symptoms return after some time, your doctor may suggest retesting to rule out a new or ongoing infection.

Visit ACE to treat H. pylori gastric infection

To treat a confirmed H. pylori gastric infection effectively and prevent long-term complications, please schedule an appointment with ACE Specialist Surgery and Endoscopy today. Our Senior Gastrointestinal specialist, Dr Reyaz Singaporewalla, will review your diagnosis and determine the most suitable H. pylori treatment plan to help eliminate the infection and restore digestive health.

References:

  1. Hu Y, Zhu Y, Lu NH. Recent progress in Helicobacter pylori treatment. Chin Med J. 2020;133(3): 335-343. doi: 10.1097/CM9.0000000000000618
  2. O’Connor A, Furuta T, Gisbert JP, et al. Review – Treatment of Helicobacter pylori infection 2020. Helicobacter. 2020;25(1):e12743. doi: 10.1111/hel.12743
  3. Ali A, AlHussaini KI. Helicobacter pylori: A Contemporary Perspective on Pathogenesis, Diagnosis and Treatment Strategies. Microorganisms. 2024;12(1):222. doi: 10.3390/microorganisms12010222
  4. Liu C, Wang Y, Shi J, et al. The status and progress of first-line treatment against Helicobacter pylori infection: a review. Ther Adv Gastroenterol. 2021;14:1-12. 10.1177/1756284821989177

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Reyaz Moiz

Dr Reyaz Singaporewalla
Senior Gastrointestinal Specialist and General Surgeon   

MBBS (Bom), MS (Surg), DNB (Surg), FRCS (Edin), MMed (Singapore), FRCSEd.